Arch Unit which received a portion of its funding from the
Arch Unit which received a portion of its funding from the United Kingdom Department of Health’s National Institute of Health Research Biomedical Research Unit funding scheme. Author details 1 Anaesthesia and Critical Care Research Unit, CE 93, MP24, E-Level, Centre Block, SP600125 biological activity University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK. 2Integrative Physiology and Critical Illness, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK. Published: 22 November5.6.7. 8.9. 10.11.12.13.14.15.16.17.18.19.20.21. References 1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE: Acute respiratory distress in adults. Lancet 1967, 2:319-323. 2. Villar J, Blanco J, A n JM, Santos-Bouza A, Blanch L, Ambr A, Gand F, Carriedo D, Mosteiro F, Basald S, Fern dez RL, Kacmarek RM; ALIEN Network: The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care 22.23.Med 2011, 37:1932-1941. Ware LB, Matthay MA: The acute respiratory distress syndrome. N Engl J Med 2000, 342:1334-1349. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R: The American uropean Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994, 149:818-824. Ferguson ND, Frutos-Vivar F, Esteban A, Fernandez-Segoviano P, Aramburu JA, Najera L, Stewart TE: Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions. Crit Care Med 2005, 33:2228-2234. Rubenfeld GD, Caldwell E, Granton J, Hudson LD, Matthay MA: Interobserver variability in applying a radiographic definition for ARDS. Chest 1999, 116:1347-1353. Soni N: PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26024392 ARDS, acronyms and the Pinocchio effect. Anaesthesia 2010, 65:976-979. Ranieri V, Rubenfeld GD, Thompson B, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, Rhodes A, Vincent JL, Bersten A, Needham D, Pesenti A: Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012, 307:2526-2533. Rooney SA, Young SL, Mendelson CR: Molecular and cellular processing of lung surfactant. FASEB J 1994, 8:957-967. Lang CJ, Postle AD, Orgeig S, Possmayer F, Bernhard W, Panda AK, Jurgens KD, Milsom WK, Nag K, Daniels CB: Dipalmitoylphosphatidylcholine is not the major surfactant phospholipid species in all mammals. Am J Physiol Regul Integr Comp Physiol 2005, 289:R1426-R1439. Schmidt R, Markart P, Ruppert C, Wygrecka M, Kuchenbuch T, Walmrath D, Seeger W, Guenther A: Time-dependent changes in pulmonary surfactant function and composition in acute respiratory distress syndrome due to pneumonia or aspiration. Respir Res 2007, 8:55. Postle AD, Heeley EL, Wilton DC: A comparison of the molecular species compositions of mammalian lung surfactant phospholipids. Comp Biochem Physiol A Mol Integr Physiol 2001, 129:65-73. Haagsman HP, Diemel RV: Surfactant-associated proteins: functions and structural variation. Comp Biochem Physiol A Mol Integr Physiol 2001, 129:91-108. Petty TL, Silvers GW, Paul GW, Stanford RE: Abnormalities in lung elastic properties and surfactant function in adult respiratory distress syndrome. Chest 1979, 75:571-574. Hallman M, Spragg R, Harrell JH, Moser KM, Gluck L: Evidence of lung surfactant abnormality in.

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