Ever, regional blood flow was only improved with dopexamine, but not with dobutamine. Microcirculatory blood flow within the gastric mucosa was also significantly enhanced with dopexamine, but not with dobutamine. Neither drug appeared to influence microcirculatory flow inside the intestinal mucosa. Conclusion: Even though the beta-adrenergic agents drastically enhanced cardiac output the mucosa of the gastrointestinal tract appeared to profit very tiny from enhanced systemic flow. Dobutamine did neither influence regional flow or microcirculatory flow. Dopexamine improved both regional and gastric mucosal flows, but had no effects on mucosal flow inside the small and huge bowel.This study was to evaluate a rebreathing process to figure out cardiac output in mechanically ventilated sufferers. Strategies: The noninvasive system is based on a lung model consisting of a ventilated and also a non-ventilated compartment, the initial major to efficient pulmonary blood flow (PBF), the latter to shunt perfusion (QVA/Qt). Within this model QVA/Qt may be calculated as QVA/Qt = (CcO2 ?CaO2) x PBF/VO2. Applying a gas mixture of soluble nitrous oxide and insoluble sulfur hexafluoride in oxygen, PBF was calculated from the uptake of N2O (PBF,rb) and oxygen uptake (VO2) from the disappearence of oxygen (VO2,rb) (AMIS 2001 Intensive Care Monitoring System, INNOVISION, Odense Denmark). CcO2 was calculated from the alveolar gas equation and CaO2 measured by gas evaluation. Thus, QVA/Qt and cardiac output (CO) might be determined by indicates in the rebreathing information (QVA/Qt,rb) (CO,rb = PBF,rb / [1 ?QVA/Qt]). Simultaneously, CO, VO2 and QVA/Qt have been determined by thermodilution (CO,thd), indirect calorimetry (VO2,ic) (Deltatrac II, Datex-Engstr , Finland) and by calculation from arterial and mixed venous blood gas analyses (QVA/Qt,bga), respectively. Right after approval by the nearby ethics committee of the medical faculty the investigations had been performed in 40 individuals on mechanical ventilation. Outcomes: CO,rb varied from 3 to 12 l/min, QVA/Qt,rb from 0.06 to 0.33 and VO2,rb from 200 to 600 ml/min. Imply values of CO,thd and CO,rb, QVA/Qt,bga and QVA/Qt,rb and VO2,ic and VO2,rbSCritical CareVol five Suppl21st International Symposium on Intensive Care and Emergency Medicinewere taken as reference values. Bias and precision have been calculated as mean distinction and typical deviation HI-TOPK-032 custom synthesis between the rebreathing and reference values in relation towards the reference values. The imply distinction between Co,rb and reference worth was ?.6 (bias), using a regular deviation of ?ten.9 (precision). The mean difference between QVA/Qt,rb and reference worth was 17.5 , with a typical deviation of 14.0 respectively; VO2 was determined with a bias of 3.4 and a precision of ?15.four . The imply difference among PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20717043 duplicate measurments connected to their mean worth accounted for 3.five .Conclusion: The present results suggest, that cardiac output, venous admixture and oxygen consumption may be reliably estimated by the proposed rebreathing strategy.Supported by INNOVISION, Denmark, giving the gasanalyser and also the pc computer software for the calculation of pulmonary blood flow and oxygen consumption (AMIS 2001 method).P150 Pulmonary embolism detected by transesophageal echocardiography in the course of cemented total hip surgery: the effects onhemodynamic, hemogasanalytic, and pulmonary shunt valuesMJ Koessler*, R Fabiani, H Hamer, RP Pitto *Department of Anesthesiology and Intensive Care, and Division of Cardiology, Waldkrankenhaus, E.