[email protected] (M.M.P.); [email protected] (O.A.G.) Department of Physiotherapy, Faculty of Continuing Health-related Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia; [email protected] Division of Neurology and Neurosurgery, Siberian State Healthcare University, 634050 Tomsk, Russia; [email protected] Correspondence: [email protected] (R.F.N.); [email protected] (N.A.S.); Tel.: 7-(812)-670-02-20 (R.F.N. N.A.S.)Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Abstract: Amyotrophic lateral sclerosis (ALS) is definitely an incurable chronic progressive neurodegenerative illness using the progressive degeneration of motor neurons in the motor cortex and reduce motor neurons inside the spinal cord as well as the brain stem. The etiology and pathogenesis of ALS are being actively studied, but there’s nonetheless no single idea. The study of ALS danger things will help to understand the mechanism of this illness improvement and, possibly, slow down the price of its progression in sufferers as well as lessen the threat of its development in persons using a predisposition toward familial ALS. The interest of researchers and clinicians within the protective role of nutrients inside the development of ALS has been growing in current years. Nevertheless, the function of a few of them just isn’t well-understood or disputed. The objective of this critique will be to analyze research around the part of nutrients as environmental components affecting the risk of building ALS and the rate of motor neuron degeneration progression. Techniques: We searched the PubMed, Springer, Clinical keys, Google Scholar, and E-Library databases for publications making use of keywords and phrases and their combinations. We Methyl jasmonate In Vivo analyzed each of the accessible studies published in 2010020. Discussion: We analyzed 39 studies, which includes randomized clinical trials, clinical instances, and meta-analyses, involving ALS patients and studies on animal models of ALS. This overview demonstrated that the following vitamins are the most substantial protectors of ALS development: vitamin B12, vitamin E vitamin C vitamin B1, vitamin B9 vitamin D vitamin B2, vitamin B6 vitamin A, and vitamin B7. In addition, this overview indicates that the part of foods using a higher content of cholesterol, polyunsaturated fatty acids, urates, and purines plays a major element in ALS improvement. Conclusion: The inclusion of vitamins along with a ketogenic diet program in disease-modifying ALS therapy can lessen the progression price of motor neuron degeneration and slow the price of illness progression, however the approach to nutrient choice should be personalized. The roles of vitamins C, D, and B7 as ALS protectors will need CFT8634 custom synthesis additional study. Key phrases: amyotrophic lateral sclerosis; predictor; threat issue; protector; nutrient; vitaminCopyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access report distributed under the terms and situations in the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).1. Introduction Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative illness with all the progressive degeneration of motor neurons inside the motor cortex andNutrients 2021, 13, 3804. https://doi.org/10.3390/nuhttps://www.mdpi.com/journal/nutrientsNutrients 2021, 13,two oflower motor neurons inside the spinal cord and also the brain stem [1]. As a rule, sufferers die from respiratory failure three years just after onset from the disease. The inci.