Latelet-derived growth PARP10 manufacturer aspect receptor, Platelet-derived development aspect receptor, LDLR-related protein 1 Platelet-derived growth element receptor, Platelet-derived development factor receptor, Sphingosine-1-phosphate receptor 1 Platelet-derived growth issue receptor, Platelet-derived development aspect receptor, Opioid development issue receptor Plexin B2 Protein tyrosine phosphatase, receptor sort, B Syndecan 1 Syndecan three Retinoic acid receptor responder 2 Reelin Semaphorin 3C Semaphorin 3F Chemokine (C-C motif) receptor-like two Integrin, 3 Plexin D1 Neuropilin 1 Neuropilin two Semaphorin 4C Semaphorin 6D Secreted frizzledrelated protein 1 Slit homolog 2 Transforming growth aspect, 1 Plexin B2 Kinase insert domain receptor Frizzled class receptor six Syndecan 1 Activin A receptor kind II ike 1 CD109 molecule Syndecan two Transforming growth element, receptor two (Continued)Table 1. ContinuedGene Pair TGFB1_TGFBR3 TGFB2_ ACVR1 TGFB2_ENG TGFB2_TGFBR2 TGFB2_TGFBR3 TGFB3_TGFBR2 TGFB3_TGFBR3 TNFSF12_ TNFRSF12A TNFSF12_ TNFRSF25 TNFSF13_FAS TNFSF13_SDC2 TNFSF13_ TNFRSF1A VEGFA_SIRPA VEGFA_TYRO3 VEGFC_FLT1 VEGFC_FLT4 VEGFC_ITGB1 VEGFC_KDR VEGFC_LYVE1 VEGFC_NRP2 WNT4_FZD6 Wingless-type MMTV integration web-site four Vascular endothelial growth element C Vascular endothelial development element A TNF superfamily, member 13 TNF superfamily, member 12 Transforming development aspect, 3 Transforming development issue, two Ligand Receptor Transforming development factor, receptor 3 Activin A receptor, form I Endoglin Transforming development aspect, receptor 2 Transforming growth element, receptor 3 Transforming growth element, receptor two Transforming growth aspect, receptor three TNF receptor superfamily, member 12A TNF receptor superfamily, member 25 Fas cell surface death receptor Syndecan 2 TNF receptor superfamily, member 1A Signal-regulatory protein TYRO3 protein tyrosine kinase Fms-related tyrosine kinase 1 Fms-related tyrosine kinase four Integrin, 1 Kinase insert domain receptor Lymphatic vessel endothelial hyaluronan rec 1 Neuropilin 2 Frizzled class receptorPTN_SDC1 PTN_SDC3 RARRES2_ CCRL2 RELN_ITGA3 SEMA3C_ PLXND1 SEMA3F_NRP1 SEMA3F_NRP2 SEMA4C_ PLD site PLXNB2 SEMA6D_KDR SFRP1_FZD6 SLIT2_SDC1 TGFB1_ ACVRL1 TGFB1_CD109 TGFB1_SDC2 TGFB1_TGFBRThis table is restricted to signaling proteins, cytokines, growth things, and chemokines. For other cell-surface ligand-receptor pairs, we refer to Information S1. BMP indicates bone morphogenetic protein; CD, cluster of differentiation; EGF, epidermal development aspect; LDLR, low-density lipoprotein receptor; MMTV, mouse mammary tumor virus; PDGF, platelet-derived development element; TEK, endothelial tyrosine kinase; TK, tyrosine kinase; TNF, tumor necrosis aspect; TYRO, tyrosine-protein kinase receptor; and Wnt, wingless-type integration web-site household, member 1.one more ten are expressed by both cardiomyocytes and fibroblasts (Table S3); just 4 are expressed especially by cardiomyocytes. If one particular considers not only the ligands however the complete 79 ligand-receptor pairs expressed by cardiomyocytes, 31 are expressed by all three cell kinds and one more 36 are expressed by each cardiomyocytes and fibroblasts; just 9 are expressed particularly by cardiomyocytes. What’s also fascinating is the fact that most ligands expressed by all three cellJ Am Heart Assoc. 2021;10:e019169. DOI: ten.1161/JAHA.120.Segers et alAutocrine Signaling in the HeartTable 2. Ligands Expressed by Cardiomyocytes, Endothelial Cells, and FibroblastsGene ADM ANGPT2 ANXA1 CTGF CXCL12 CYR61 DKK1 GAS6 HGF IGF2 JAG1 MDK NPPB PDAP1 PDG.