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RORĪ² medchemexpress schizophrenia is usually a complex psychiatric disorder having a lifetime morbidity rate of 0.five.0 . Accumulating proof indicates that DNA methylation, that is the addition of a methyl group for the cytosine in a CpG dinucleotide, may play an important function within the pathogenesis of schizophrenia. As an example, L-methionine, a precursor of S-adenosylmethionine, which donates its methyl group to a variety of acceptors, exacerbates the psychotic symptoms of schizophrenia individuals (Pollin et al., 1961; Cohen et al., 1974). L-methionine-treated mice exhibited elevated DNA methylation that was accompanied by decreased mRNA levels of certain genes, and by behavioral adjustments related to those noticed in schizophrenia (Tremolizzo et al., 2002, 2005). Moreover, an improved mRNA expression of DNA methyl-transferases (DNMT1 and DNMT3a) has been observed in schizophrenia (Veldic et al., 2004, 2005; Ruzicka et al., 2007; Zhubi et al., 2009). In addition, aberrant DNA methylation in brains of individuals with schizophrenia (Abdolmaleky et al., 2005, 2006, 2011; Grayson et al., 2005; Iwamoto et al., 2005; Tamura et al., 2007; Mill et al., 2008;Tolosa et al., 2010; Wockner et al., 2014) plus the associations of distinct DNA methylation patterns with phenotypic discordance of schizophrenia between twins (Petronis et al., 2003; Dempster et al., 2011; Kinoshita et al., 2013) have been reported. On the other hand, the sample sizes in these prior epigenetic research of schizophrenia have been comparatively smaller plus the quantity of CpG internet sites interrogated was limited. Tissue-specific differences in DNA methylation have already been extensiv.