D The Worshipful Enterprise of Pewterers.Reference List1. Sutton MA, Wall NR, Aakalu GN, Schuman EM. Regulation of dendritic protein synthesis by miniature synaptic events. Science. 2004; 304:1979983. [PubMed: 15218151] 2. McKinney RA, Capogna M, Durr R, Gahwiler BH, Thompson SM. Miniature synaptic events retain dendritic spines via AMPA receptor activation. Nat. Neurosci. 1999; two:449. [PubMed: 10195179] three. Groffen AJ, et al. Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science. 2010; 327:1614618. [PubMed: 20150444] 4. Xu J, Pang ZP, Shin OH, Sudhof TC. Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat. Neurosci. 2009; 12:75966. [PubMed: 19412166] 5. Eggermann E, Bucurenciu I, Goswami SP, Jonas P. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at rapid mammalian synapses. Nat. Rev. Neurosci. 2011; 13:71. [PubMed: 22183436] six. Williams C, et al. Coactivation of various tightly coupled calcium channels triggers spontaneous release of GABA. Nat. Neurosci. 2012; 15:1195197. 7. Goswami SP, Bucurenciu I, Jonas P. Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca2+ Channels via Microdomain Coupling. J. Neurosci. 2012; 32:142944304. [PubMed: 23055500] 8. Vyleta NP, Smith SM. Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor. J. Neurosci. 2011; 31:4593606. [PubMed: 21430159] 9. Scanziani M, Capogna M, Gahwiler BH, Thompson SM. Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine within the hippocampus. Neuron. 1992; 9:919927. [PubMed: 1358131] ten. Wu LG, Saggau P. Pharmacological identification of two kinds of presynaptic voltage-dependent calcium channels at CA3-CA1 synapses of the hippocampus. J. Neurosci. 1994; 14:5613622. [PubMed: 8083757] 11. Sheng J, et al. Calcium-channel quantity critically influences synaptic strength and plasticity in the active zone. Nat. Neurosci. 2012; 15:998006. [PubMed: 22683682] 12. Li L, Bischofberger J, Jonas P. Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons. J. Neurosci. 2007; 27:134203429.Sparfloxacin [PubMed: 18057200] 13.Nicardipine hydrochloride Reid CA, Bekkers JM, Clements JD. N- and P/Q-type Ca2+ channels mediate transmitter release using a equivalent cooperativity at rat hippocampal autapses.PMID:24670464 J. Neurosci. 1998; 18:2849855. [PubMed: 9526002] 14. Mintz IM, Sabatini BL, Regehr WG. Calcium handle of transmitter release at a cerebellar synapse. Neuron. 1995; 15:67588. [PubMed: 7546746]Nat Neurosci. Author manuscript; readily available in PMC 2014 September 27.Ermolyuk et al.Page15. Holderith N, et al. Release probability of hippocampal glutamatergic terminals scales using the size of the active zone. Nat. Neurosci. 2012; 15:98897. [PubMed: 22683683] 16. Soong TW, et al. Structure and functional expression of a member of the low voltage-activated calcium channel household. Science. 1993; 260:1133136. [PubMed: 8388125] 17. Regehr WG, Atluri PP. Calcium transients in cerebellar granule cell presynaptic terminals. Biophys. J. 1995; 68:2156170. [PubMed: 7612860] 18. Xu B, et al. Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis by way of Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network. PLoS One. 2011; six:e19052. [PubMed: 21544200] 19. Lou X, Scheuss V, Schneggenburger R. Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion. Nature. 2005; 435:49.