Product Name :
CHK1-IN-3
Description:
CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM.
CAS:
2097252-39-4
Molecular Weight:
405.46
Formula:
C20H23N9O
Chemical Name:
5-{[5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl]amino}-3-[(3R)-piperidin-3-yloxy]pyridine-2-carbonitrile
Smiles :
CNC1=NC(NC2=CC(O[C@H]3CNCCC3)=C(C#N)N=C2)=NC=C1C1C=NN(C)C=1
InChiKey:
SLCNIAWQMQCAFR-OAHLLOKOSA-N
InChi :
InChI=1S/C20H23N9O/c1-22-19-16(13-8-26-29(2)12-13)11-25-20(28-19)27-14-6-18(17(7-21)24-9-14)30-15-4-3-5-23-10-15/h6,8-9,11-12,15,23H,3-5,10H2,1-2H3,(H2,22,25,27,28)/t15-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM.|Product information|CAS Number: 2097252-39-4|Molecular Weight: 405.46|Formula: C20H23N9O|Chemical Name: 5-{[5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl]amino}-3-[(3R)-piperidin-3-yloxy]pyridine-2-carbonitrile|Smiles: CNC1=NC(NC2=CC(O[C@H]3CNCCC3)=C(C#N)N=C2)=NC=C1C1C=NN(C)C=1|InChiKey: SLCNIAWQMQCAFR-OAHLLOKOSA-N|InChi: InChI=1S/C20H23N9O/c1-22-19-16(13-8-26-29(2)12-13)11-25-20(28-19)27-14-6-18(17(7-21)24-9-14)30-15-4-3-5-23-10-15/h6,8-9,11-12,15,23H,3-5,10H2,1-2H3,(H2,22,25,27,28)/t15-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Doxepin} MedChemExpress|{Doxepin} Metabolic Enzyme/Protease|{Doxepin} Biological Activity|{Doxepin} In stock|{Doxepin} supplier|{Doxepin} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Tadalafil} site|{Tadalafil} Apoptosis|{Tadalafil} Technical Information|{Tadalafil} Data Sheet|{Tadalafil} custom synthesis|{Tadalafil} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35126464 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM) and displays low affinity for hERG (IC50 > 40 µM).|In Vivo:|CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected.|Products are for research use only. Not for human use.|