Product Name :
COH000
Description:
COH000 is an allosteric, covalent and irreversible ubiquitin-like 1-activating enzyme (SUMO-activating enzyme / E1) inhibitor with IC50 of 0.2 μM for SUMOylation in vitro.
CAS:
1534358-79-6
Molecular Weight:
419.47
Formula:
C25H25NO5
Chemical Name:
dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo [2.2.1]hepta-2,5-diene-2,3-dicarboxylate
Smiles :
CC1C=CC(C[C@@H](NC2C=CC=CC=2)C23C=CC(O2)C(=C3C(=O)OC)C(=O)OC)=CC=1
InChiKey:
UFPINDDCTUCUSA-ABGUIGEDSA-N
InChi :
InChI=1S/C25H25NO5/c1-16-9-11-17(12-10-16)15-20(26-18-7-5-4-6-8-18)25-14-13-19(31-25)21(23(27)29-2)22(25)24(28)30-3/h4-14,19-20,26H,15H2,1-3H3/t19?,20-,25?/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Troglitazone} site|{Troglitazone} Autophagy|{Troglitazone} Protocol|{Troglitazone} Formula|{Troglitazone} supplier|{Troglitazone} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Alpelisib} medchemexpress|{Alpelisib} PI3K|{Alpelisib} Purity & Documentation|{Alpelisib} Purity|{Alpelisib} custom synthesis|{Alpelisib} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23075432
Additional information:
COH000 is an allosteric, covalent and irreversible ubiquitin-like 1-activating enzyme (SUMO-activating enzyme / E1) inhibitor with IC50 of 0.2 μM for SUMOylation in vitro.|Product information|CAS Number: 1534358-79-6|Molecular Weight: 419.47|Formula: C25H25NO5|Chemical Name: dimethyl 1-((R)-1-(phenylamino)-2-(p-tolyl)ethyl)-7-oxabicyclo [2.2.1]hepta-2,5-diene-2,3-dicarboxylate|Smiles: CC1C=CC(C[C@@H](NC2C=CC=CC=2)C23C=CC(O2)C(=C3C(=O)OC)C(=O)OC)=CC=1|InChiKey: UFPINDDCTUCUSA-ABGUIGEDSA-N|InChi: InChI=1S/C25H25NO5/c1-16-9-11-17(12-10-16)15-20(26-18-7-5-4-6-8-18)25-14-13-19(31-25)21(23(27)29-2)22(25)24(28)30-3/h4-14,19-20,26H,15H2,1-3H3/t19?,20-,25?/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO 50 mg/mL (119.20 mM) Ethanol 1 mg/mL (2.38 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Yi-Jia Li, et al. Cell Chem Biol. 2019 Feb 21;26(2):278-288.e6.Products are for research use only. Not for human use.|