Effects of KU-55933 on HCT116 p53+/+ and HCT116 p532/ 2 CellsWe examined the effects of KU-55933 on mitochondrial function as assessed by reduction of resazurin in isogenic p53 wild type…
Angiotensin converting enzyme inhibitors (ACE-I) and HMGCoA reductase inhibitors (`statins') have been shown to reduce CVD risk through their BP and cholesterol lowering properties, respectively . However, both classes of…
Neuraminidase AssayNeuraminidase activity was measured using a commercially available chemiluminescent kit, NA-Star (Applied Biosystems, Foster City, CA, USA), which includes a chemiluminescent substrate, 1,2-dioxetane derivative of sialic acid (sodium(2chloro-5-(4-methoxyspiro1,2-dioxetane-3,29-(5-chloro)tricyclo decan-4-yl-phenyl-5-acetamido-3,5-dideoxy-a-D-glycero-D-galacto-2-nonulopyranoside)onate),…
Antimicrobial Susceptibility TestingThe 18 compounds were then tested for their ability to suppress the growth of N. gonorrhoeae FA19 using the disc diffusion zone method. Eleven compounds did not suppress…