The original step of O-glycosylation is catalysed by a hugely conserved family of integral ER membrane proteins, the protein-O-mannosyltransferases (Pmt’s) [eleven]
Protein-O-glycosylation is an crucial, evolutionary conserved protein modification that has been studied extensively in the yeasts Saccharomyces cerevisiae and Candida albicans. This method has also been identified in other fungal…