These experiments demonstrate that Cyp26 expression in endoderm is without a doubt RA-dependent and also demonstrate an energetic endogenous RA pathway in endoderm at gastrulation and somitogenesis
The RA antagonist AGN193109 was synthesized at Novo Nordisk A/S (DK) . Its activity was examined in RA-responsive P19 embryonic carcinoma cells employing RARb, a direct goal of RA signaling,…