G. Wrote the paper: AG RSH JM. References 1. Artavanis-Tsakonas S, Rand MD, Lake RJ Notch signaling: Cell fate handle and signal integration in development. Science 284: 770776. 2. Gridley T Notch ��-Sitosterol ��-D-glucoside price signaling in vertebrate improvement and illness. Mol Cell Neurosci 9: 103108. three. Radtke F, Wilson A, MacDonald H Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila. Bioessays 27: 11171128. 4. Yoon K, Gaiano N Notch signaling in the Tubastatin A site Mammalian central nervous method: insights from mouse mutants. Nat Neurosci 8: 709715. 5. Bolos V, Grego-Bessa J, la Pompa de JL Notch signaling in development and cancer. Endocrine Testimonials 28: 339363. 6. Thomas U, Speicher SA, Knust E The Drosophila gene Serrate encodes an EGF-like transmembrane protein using a complex expression pattern in embryos and wing discs. Improvement 111: 749761. 7. Vassin H, Campos-Ortega JA Genetic Analysis of Delta, a Neurogenic Gene of Drosophila melanogaster. Genetics 116: 433445. 8. Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43: 567581. 9. Fortini ME, Artavanis-Tsakonas S The suppressor of hairless protein participates in notch receptor signaling. Cell 79: 273282. ten. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, et al. Signalling downstream of activated mammalian Notch. Nature 377: 355358. 11. Jarriault S, Le Bail O, Hirsinger E, Pourquie O, Logeat F, et al. Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol 18: 74237431. 12. Kidd S, Lieber T, Young MW Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev 12: 37283740. 13. Kopan R, Schroeter EH, Weintraub H, Nye JS Signal transduction by activated mNotch: value of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 93: 16831688. 14. Schroeter E, Kisslinger J, Kopan R Notch-1 signalling needs ligandinduced proteolytic release of intracellular domain. Nature 393: 382386. 15. Struhl G, Adachi A Nuclear access and action of notch in vivo. Cell 93: 649660. 16. Okajima T, Irvine KD Regulation of notch signaling by o-linked fucose. Cell 111: 893904. 17. Shi S, Stanley P Protein O-fucosyltransferase 1 is an important element of Notch signaling pathways. 18325633 Proc Natl Acad Sci USA 100: 52345239. 18. Wang Y, Shao L, Shi S, Harris R, Spellman M, et al. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J Biol Chem 276: 4033840345. eight POFUT1 in DLL1 Function 19. Moloney DJ, Shair LH, Lu FM, Xia J, Locke R, et al. Mammalian Notch1 is modified with two uncommon forms of O-linked glycosylation discovered on epidermal growth factor-like modules. J Biol Chem 275: 96049611. 20. Shao L, Moloney D, Haltiwanger RS Fringe modifies O-fucose on mouse Notch1 at epidermal development factor-like repeats within the ligand-binding web-site and the Abruptex region. J Biol Chem 278: 77757782. 21. Bruckner K, Perez L, Clausen H, Cohen S Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406: 411415. 22. Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, et al. Fringe is usually a glycosyltransferase that modifies Notch. Nature 406: 369375. 23. Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, et al. Fringe differentially modulates.G. Wrote the paper: AG RSH JM. References 1. Artavanis-Tsakonas S, Rand MD, Lake RJ Notch signaling: Cell fate manage and signal integration in improvement. Science 284: 770776. 2. Gridley T Notch signaling in vertebrate development and illness. Mol Cell Neurosci 9: 103108. three. Radtke F, Wilson A, MacDonald H Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila. Bioessays 27: 11171128. four. Yoon K, Gaiano N Notch signaling within the mammalian central nervous technique: insights from mouse mutants. Nat Neurosci 8: 709715. 5. Bolos V, Grego-Bessa J, la Pompa de JL Notch signaling in improvement and cancer. Endocrine Critiques 28: 339363. six. Thomas U, Speicher SA, Knust E The Drosophila gene Serrate encodes an EGF-like transmembrane protein using a complex expression pattern in embryos and wing discs. Improvement 111: 749761. 7. Vassin H, Campos-Ortega JA Genetic Evaluation of Delta, a Neurogenic Gene of Drosophila melanogaster. Genetics 116: 433445. 8. Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S Nucleotide sequence from the neurogenic locus notch implies a gene solution that shares homology with proteins containing EGF-like repeats. Cell 43: 567581. 9. Fortini ME, Artavanis-Tsakonas S The suppressor of hairless protein participates in notch receptor signaling. Cell 79: 273282. 10. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, et al. Signalling downstream of activated mammalian Notch. Nature 377: 355358. 11. Jarriault S, Le Bail O, Hirsinger E, Pourquie O, Logeat F, et al. Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol 18: 74237431. 12. Kidd S, Lieber T, Young MW Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev 12: 37283740. 13. Kopan R, Schroeter EH, Weintraub H, Nye JS Signal transduction by activated mNotch: value of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 93: 16831688. 14. Schroeter E, Kisslinger J, Kopan R Notch-1 signalling requires ligandinduced proteolytic release of intracellular domain. Nature 393: 382386. 15. Struhl G, Adachi A Nuclear access and action of notch in vivo. Cell 93: 649660. 16. Okajima T, Irvine KD Regulation of notch signaling by o-linked fucose. Cell 111: 893904. 17. Shi S, Stanley P Protein O-fucosyltransferase 1 is an vital component of Notch signaling pathways. 18325633 Proc Natl Acad Sci USA one hundred: 52345239. 18. Wang Y, Shao L, Shi S, Harris R, Spellman M, et al. Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase. J Biol Chem 276: 4033840345. 8 POFUT1 in DLL1 Function 19. Moloney DJ, Shair LH, Lu FM, Xia J, Locke R, et al. Mammalian Notch1 is modified with two uncommon forms of O-linked glycosylation identified on epidermal development factor-like modules. J Biol Chem 275: 96049611. 20. Shao L, Moloney D, Haltiwanger RS Fringe modifies O-fucose on mouse Notch1 at epidermal development factor-like repeats inside the ligand-binding website along with the Abruptex region. J Biol Chem 278: 77757782. 21. Bruckner K, Perez L, Clausen H, Cohen S Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406: 411415. 22. Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, et al. Fringe is a glycosyltransferase that modifies Notch. Nature 406: 369375. 23. Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, et al. Fringe differentially modulates.