Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection

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Journal of the International AIDS SocietyPoster presentationBioMed CentralOpen AccessEtravirine use in clinical practice: 48-week data from a single centre cohortC Scott*, N Khatib, M Bower, BG Gazzard and M NelsonAddress: Chelsea Westminster Hospital NHS Foundation Trust, London, UK * Corresponding authorfrom Ninth International Congress on Drug Therapy in HIV Infection Glasgow, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25636517 UK. 9?3 November 2008 Published: 10 November 2008 Journal of the International AIDS Society 2008, 11(Suppl 1):P49 doi:10.1186/1758-2652-11-S1-P Meeting abstracts ?A single PDF containing all abstracts in this Supplement PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27488460 is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf This abstract is available from: http://www.jiasociety.org/content/11/S1/P49 ?2008 Scott et al; licensee BioMed Central Ltd.BackgroundEtravirine (ETV) is a next generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with activity against wild-type and NNRTI-resistant HIV-1. We present our experience with ETV from the Chelsea Westminster cohortnucleoside analogues. 48 of patients had one or more NNRTI resistance associated mutations (RAMs). 44 patients switched with an undetectable VL. 37 patients had 1 NNRTI RAMs. One discontinuation seen due to CNS toxicity. 54 patients switched with a detectable viral load. 57 patients had 1 NNRTI RAMs. Eight discontinuations seen in this group. Reasons for discontinuation: lost to follow-up (three), rash (one), diarrhoea (one), CNS toxicity (one), no virological response to ETV (one), and death due to pre-existing lymphoma (one).MethodsData were retrospectively collected from patients eligible for the ETV expanded access program. Individuals received ETV 200 mg BID plus an optimised background regimen (OBR). OBR consisted of reverse transcriptase inhibitors +/- protease inhibitors +/- entry/fusion inhibitors +/- integrase inhibitors. Baseline patient characteristics were analysed. CD4 cell count and viral load (VL) were measured at baseline, 12, 24, 36 and 48 weeks.Patients switched to ETV with 1 NNRTI RAMData were available for 29 patients at week 48 who switched to ETV with known NNRTI resistance. At week 48, 94 patients on treatment had an undetectable VL.Summary of results98 patients were enrolled into the EAP. Median (range) baseline characteristics included CD4: 268 cells/mm3 (8?43), viral load: 10,283 copies/ml (<50?00,000), drugs in OBR: 2 (1?). 46/98 patients used daruvanir, 41/ 98 used raltegravir, 5/98 used enfuvirtide and 4/98 used maraviroc in OBR. 31/98 patients used ETV with twoTable 1: Patients switched to ETV with an undetectable viral loadConclusionETV in combination with OBR is successful in achieving virological suppression in treatment-experienced patients. ETV is also an effective alternative in patients who need to switch due to drug toxicity. ETV is a well tolerated agent.VL< 50 copies/ml Intention to treat On treatment12 weeks (n = 36) 100 10024 weeks (n = 24) 88 9136 weeks (n = 17) 94 10048 weeks (n = 8) 88 100Page 1 of(page number not for citation purposes)Journal of the International AIDS Society 2008, 11(Suppl 1):Phttp://www.jiasociety.org/content/11/S1/PTable 2: Patients switched to.