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Disinfection therapy, in which hydroxyl radicals generated by photolysis of hydrogen peroxide (H2O2) kill bacteria efficiently, has been developed in our laboratory [1,2]. In vitro studies discovered that Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis, and Aggregatibacter actinomycetemcomitans were killed using a .5-log reduction of viable counts within three min when bacterial suspension in 1 M H2O2 was irradiated with laser light at 405 nm [1]. One particular molar H2O2 corresponds to roughly 3 , which can be a concentration utilised as a disinfectant for skin and oral mucosa. A subcommittee with the US Meals and Drug Administration also concluded that H2O2 is protected at concentrations of as much as three [3]. Along with in vitro findings, an in vivo antibacterial impact of this disinfection system was confirmed successful within a rat model of superficial S. aureus infection [4]. Antibiotic-resistant bacteria are constantly emerging as a result of the widespread and often indiscriminate use of antibiotics in the healthcare field [5,6]. Reactive oxygen species (ROS), like hydroxyl radicals and singlet oxygen, non-specifically oxidize quite a few cell structures, top to cell death [7?]. Consequently, it can be unlikely that bacteria would develop resistance towards the cytotoxic action of ROS [7?0]. Thus, disinfection remedy usingphotolysis of H2O2 is not anticipated to induce bacterial r.