Product Name :
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH
Description:
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).
CAS:
2378261-80-2
Molecular Weight:
477.59
Formula:
C23H43NO9
Chemical Name:
tert-butyl (2S,4R)-2-(hydroxymethyl)-4-[2-(2-{2-[2-(oxan-2-yloxy)ethoxy]ethoxy}ethoxy)ethoxy]pyrrolidine-1-carboxylate
Smiles :
CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1CO)OCCOCCOCCOCCOC1CCCCO1
InChiKey:
ZKEBNPQGNDNRDY-MCOCGALXSA-N
InChi :
InChI=1S/C23H43NO9/c1-23(2,3)33-22(26)24-17-20(16-19(24)18-25)30-14-12-28-10-8-27-9-11-29-13-15-32-21-6-4-5-7-31-21/h19-21,25H,4-18H2,1-3H3/t19-,20+,21?/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Zoliflodacin} medchemexpress|{Zoliflodacin} DNA/RNA Synthesis|{Zoliflodacin} Technical Information|{Zoliflodacin} Purity|{Zoliflodacin} supplier|{Zoliflodacin} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Vinpocetine} site|{Vinpocetine} NF-κB|{Vinpocetine} Protocol|{Vinpocetine} In Vivo|{Vinpocetine} manufacturer|{Vinpocetine} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).|Product information|CAS Number: 2378261-80-2|Molecular Weight: 477.59|Formula: C23H43NO9|Chemical Name: tert-butyl (2S,4R)-2-(hydroxymethyl)-4-[2-(2-{2-[2-(oxan-2-yloxy)ethoxy]ethoxy}ethoxy)ethoxy]pyrrolidine-1-carboxylate|Smiles: CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1CO)OCCOCCOCCOCCOC1CCCCO1|InChiKey: ZKEBNPQGNDNRDY-MCOCGALXSA-N|InChi: InChI=1S/C23H43NO9/c1-23(2,3)33-22(26)24-17-20(16-19(24)18-25)30-14-12-28-10-8-27-9-11-29-13-15-32-21-6-4-5-7-31-21/h19-21,25H,4-18H2,1-3H3/t19-,20+,21?/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24220671 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|