Product Name :
TP3011
Description:
TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro.
CAS:
534605-74-8
Molecular Weight:
474.51
Formula:
C26H26N4O5
Chemical Name:
(10S)-10-ethyl-10-hydroxy-23-pentyl-8-oxa-4,15,21,23-tetraazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1(24),2(14),6(11),12,15,17,19-heptaene-5,9,22-trione
Smiles :
CCCCCN1C2=C3C(=CC=CC3=NC3C4=CC5=C(COC(=O)[C@]5(O)CC)C(=O)N4CC=32)NC1=O
InChiKey:
SEFCGEILTGZHAO-SANMLTNESA-N
InChi :
InChI=1S/C26H26N4O5/c1-3-5-6-10-29-22-14-12-30-19(11-16-15(23(30)31)13-35-24(32)26(16,34)4-2)21(14)27-17-8-7-9-18(20(17)22)28-25(29)33/h7-9,11,34H,3-6,10,12-13H2,1-2H3,(H,28,33)/t26-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Atoltivimab} medchemexpress|{Atoltivimab} Filovirus|{Atoltivimab} Protocol|{Atoltivimab} In Vitro|{Atoltivimab} manufacturer|{Atoltivimab} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TP3011 (CH0793011) is an active metabolite of CH-0793076 and is a potent topoisomerase I inhibitor equipotent as SN38. TP3011 is against cancer cell lines growth with IC50s at the range sub-nanomolar in vitro.|Product information|CAS Number: 534605-74-8|Molecular Weight: 474.51|Formula: C26H26N4O5|Chemical Name: (10S)-10-ethyl-10-hydroxy-23-pentyl-8-oxa-4,15,21,23-tetraazahexacyclo[14.7.1.0²,¹⁴.0⁴,¹³.0⁶,¹¹.0²⁰,²⁴]tetracosa-1(24),2(14),6(11),12,15,17,19-heptaene-5,9,22-trione|Smiles: CCCCCN1C2=C3C(=CC=CC3=NC3C4=CC5=C(COC(=O)[C@]5(O)CC)C(=O)N4CC=32)NC1=O|InChiKey: SEFCGEILTGZHAO-SANMLTNESA-N|InChi: InChI=1S/C26H26N4O5/c1-3-5-6-10-29-22-14-12-30-19(11-16-15(23(30)31)13-35-24(32)26(16,34)4-2)21(14)27-17-8-7-9-18(20(17)22)28-25(29)33/h7-9,11,34H,3-6,10,12-13H2,1-2H3,(H,28,33)/t26-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ezabenlimab} MedChemExpress|{Ezabenlimab} Immunology/Inflammation|{Ezabenlimab} Biological Activity|{Ezabenlimab} References|{Ezabenlimab} custom synthesis|{Ezabenlimab} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:24189672 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TP3011 (0-100 nM; 72 hours) (compound 6c) inhibits cell proliferative activities against various human cancer cell lines, producing 50% inhibition (IC50) of cell growth of 0.85 nM; 8.5 nM; and 8.2 nM in HCT116, QG56, and NCI-H460 (NSCLC) cells, respectively.|Products are for research use only. Not for human use.|