Product Name :
Naringin (Naringoside)
Description:
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.
CAS:
10236-47-2
Molecular Weight:
580.53
Formula:
C27H32O14
Chemical Name:
(2S)-7-{[(2S, 3R, 4S, 5S, 6R)-4, 5-dihydroxy-6-(hydroxymethyl)-3-{[(2S, 3R, 4R, 5R, 6S)-3, 4, 5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-3, 4-dihydro-2H-1-benzopyran-4-one
Smiles :
C[C@@H]1O[C@@H](O[C@H]2[C@H](OC3C=C4O[C@@H](CC(=O)C4=C(O)C=3)C3C=CC(O)=CC=3)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
InChiKey:
DFPMSGMNTNDNHN-ZPHOTFPESA-N
InChi :
InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.|Product information|CAS Number: 10236-47-2|Molecular Weight: 580.53|Formula: C27H32O14|Synonym:|Aurantiin|AI3-19008|AI319008|AI3 19008|Naringin|Naringoside|Chemical Name: (2S)-7-{[(2S, 3R, 4S, 5S, 6R)-4, 5-dihydroxy-6-(hydroxymethyl)-3-{[(2S, 3R, 4R, 5R, 6S)-3, 4, 5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-3, 4-dihydro-2H-1-benzopyran-4-one|Smiles: C[C@@H]1O[C@@H](O[C@H]2[C@H](OC3C=C4O[C@@H](CC(=O)C4=C(O)C=3)C3C=CC(O)=CC=3)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O|InChiKey: DFPMSGMNTNDNHN-ZPHOTFPESA-N|InChi: InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 100 mg/mL(172.{{Tesofensine} site|{Tesofensine} Neuronal Signaling|{Tesofensine} Biological Activity|{Tesofensine} References|{Tesofensine} custom synthesis|{Tesofensine} Epigenetics} 25 mM).{{DBCO-Biotin} site|{DBCO-Biotin} PROTAC|{DBCO-Biotin} Immunology/Inflammation|{DBCO-Biotin} Purity & Documentation|{DBCO-Biotin} In Vitro|{DBCO-Biotin} custom synthesis} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23537004 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Naringin is a flavanone glycoside, which gives the grapefruit juice its bitter taste. Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Naringin is also an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis. In addition, Naringin reduces diabetes-induced neuropathy in rats.|In Vivo:|LD50: Mice 1650mg/kg.|References:|Kandhare AD, et al. Fitoterapia, 2012, 83(4), 650-659.Schindler R, et al. J Nutr, 2006, 136(6), 1477-1482.Ueng YF, et al. Life Sci, 1999, 65(24), 2591-2602.Products are for research use only. Not for human use.|