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NKX2.2 Recombinant monoclonal antibody (NX2/1422R)
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NKX2.2 acts as a transcriptional activator. Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis.
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| Alternative Name Homeobox protein Nkx-2.{{1119517-19-9} site|{1119517-19-9} Purity & Documentation|{1119517-19-9} Formula|{1119517-19-9} manufacturer} 2 | Application Flow Cytometry, IF, IHC (PS) | Application Notes Antibody to NKX2.2 detects a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors. | Clone NX2/1422R | Formulation Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. | Gene/Protein Identifier 4821 (Gene ID) | Host Rabbit | Immunogen Recombinant human NKX2.{{34981-26-5} MedChemExpress|{34981-26-5} Technical Information|{34981-26-5} Purity|{34981-26-5} manufacturer} 2 protein fragment.PMID:30725763 | Isotype IgGκ | Recommendation Dilutions/Conditions Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL)Immunofluorescence (1-2 µg/mL)Immunohistochemistry (formalin-fixed paraffin sections) (1-2 µg/mL for 30 minutes at RT)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human | UniProt ID O95096 | Unit of Measure (UM) µg