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Pregnancy-associated plasma protein A (human) monoclonal antibody (PAPP A 1-24)
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Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).
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| Alternative Name PAPP-A, Pappalysin-1, Insulin-like growth factor binding protein-4 protease | Application ELISA, IHC, WB | Clone PAPP A 1-24 | Formulation Liquid. In 0.{{2222635-15-4} web|{2222635-15-4} Protocol|{2222635-15-4} Data Sheet|{2222635-15-4} custom synthesis} 01M phosphate buffer, pH 7.{{2928571-43-9} MedChemExpress|{2928571-43-9} Biological Activity|{2928571-43-9} Purity|{2928571-43-9} supplier} 4, containing 0.PMID:30085565 5M sodium chloride and 15mM sodium azide. | GenBank ID 5069 | Host Mouse | Immunogen Purified human PAPP-A. | Isotype IgG1κ | Source From culture supernatant. | Species Reactivity Human | Specificity Specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. | UniProt ID Q13219 | Unit of Measure (UM) mg, µg