Product Name :
Dehydroleucodine
Description:
Dehydroleucodine is a sesquiterpene lactone isolated from Gynoxys verrucosa. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects.
CAS:
36150-07-9
Molecular Weight:
244.29
Formula:
C15H16O3
Chemical Name:
(3aS, 9aS, 9bS)-6, 9-dimethyl-3-methylidene-2H, 3H, 3aH, 4H, 5H, 7H, 9aH, 9bH-azuleno[4, 5-b]furan-2, 7-dione
Smiles :
CC1CC[C@@H]2[C@H](OC(=O)C2=C)[C@@H]2C=1C(=O)C=C2C
InChiKey:
SKNVIAFTENCNGB-BPNCWPANSA-N
InChi :
InChI=1S/C15H16O3/c1-7-4-5-10-9(3)15(17)18-14(10)13-8(2)6-11(16)12(7)13/h6,10,13-14H,3-5H2,1-2H3/t10-,13-,14-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Obefazimod Epigenetic Reader Domain
Shelf Life:
≥12 months if stored properly.Piroxicam Data Sheet
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33319692
Additional information:
Dehydroleucodine is a sesquiterpene lactone isolated from Gynoxys verrucosa. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects.|Product information|CAS Number: 36150-07-9|Molecular Weight: 244.29|Formula: C15H16O3|Chemical Name: (3aS, 9aS, 9bS)-6, 9-dimethyl-3-methylidene-2H, 3H, 3aH, 4H, 5H, 7H, 9aH, 9bH-azuleno[4, 5-b]furan-2, 7-dione|Smiles: CC1CC[C@@H]2[C@H](OC(=O)C2=C)[C@@H]2C=1C(=O)C=C2C|InChiKey: SKNVIAFTENCNGB-BPNCWPANSA-N|InChi: InChI=1S/C15H16O3/c1-7-4-5-10-9(3)15(17)18-14(10)13-8(2)6-11(16)12(7)13/h6,10,13-14H,3-5H2,1-2H3/t10-,13-,14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Paola E Ordóñez, et al. Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells. J Nat Prod. 2016 Apr 22;79(4):691-6.Mariano E Vera, et al. Activation of human leukemic mast cell line LAD2 is modulated by dehydroleucodine and xanthatin. Leuk Lymphoma. 2012 Sep;53(9):1795-803.Valeria V Costantino, et al. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis. Cancer Lett. 2016 Mar 1;372(1):10-23.Products are for research use only. Not for human use.|