Product Name :
Ro-15-2041
Description:
Ro 15-2041 is a selective platelet phosphodiesterase inhibitor with antithrombotic properties.
CAS:
77448-87-4
Molecular Weight:
294.15
Formula:
C12H12BrN3O
Chemical Name:
7-bromo-3,6-dimethyl-2H,3H,5H,10H-imidazo[2,1-b]quinazolin-2-one
Smiles :
CC1C2CN3C(C)C(=O)N=C3NC=2C=CC=1Br
InChiKey:
IASFSCWLFJGXQL-UHFFFAOYSA-N
InChi :
InChI=1S/C12H12BrN3O/c1-6-8-5-16-7(2)11(17)15-12(16)14-10(8)4-3-9(6)13/h3-4,7H,5H2,1-2H3,(H,14,15,17)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Pindolol manufacturer
Additional information:
Ro 15-2041 is a selective platelet phosphodiesterase inhibitor with antithrombotic properties.Alefacept Description |Product information|CAS Number: 77448-87-4|Molecular Weight: 294.15|Formula: C12H12BrN3O|Chemical Name: 7-bromo-3,6-dimethyl-2H,3H,5H,10H-imidazo[2,1-b]quinazolin-2-one|Smiles: CC1C2CN3C(C)C(=O)N=C3NC=2C=CC=1Br|InChiKey: IASFSCWLFJGXQL-UHFFFAOYSA-N|InChi: InChI=1S/C12H12BrN3O/c1-6-8-5-16-7(2)11(17)15-12(16)14-10(8)4-3-9(6)13/h3-4,7H,5H2,1-2H3,(H,14,15,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ro 15-2041 inhibits platelet aggregation induced by all common platelet agonists in platelet-rich plasma obtained from various species including man (IC50=1-3 μM). Ro 15-2041 potentiates platelet inhibition by prostacyclin, the prostacyclin-induced increase of intraplatelet cyclic (c) AMP levels and inhibits the collagen-induced release of serotonin and beta-thromboglobulin. Ro 15-2041 reduces the increase and accelerated the normalization of cytosolic free Ca2+ in thrombin-stimulated human platelets.PMID:32668837 Ro 15-2041 is a potent (IC50=70 nM) and selective inhibitor of platelet cAMP-phosphodiesterase activity. Whereas Ro 15-2041 causes complete inhibition of cAMP-phosphodiesterase activity in human platelet supernatants, breakdown of cAMP in cardiac homogenates is depressed to maximally 50%. In human brain and rabbit uterus Ro 15-2041 is at least 1000 times less potent. By comparison, papaverine fully inhibits phosphodiesterase activity in all four tissues with similar IC50 values of about 5 μM. Furthermore, Ro 15-2041 selectively inhibits cAMP-phosphodiesterase activity of a bovine calmodulin-independent but not of a calmodulin-dependent enzyme preparation.|Products are for research use only. Not for human use.|