Our final results curiously showed that when the dileucine motif (L344-345) at the C-terminus of D1R was mutated, the mutant protein was not ready to site visitors to the plasma membrane rather, it was localized in the early endosome
In this experiment, cAMP accumulation did not boost in di-L mutant D1R expressing1494675-86-3 cells. These benefits confirmed our hypothesis and suggested that di-L motif performs an crucial purpose in the…